Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation (for a review, Veiga et al. ). Lonomia obliqua (Walker, ) is a moth from the family Saturniidae, widely distributed in tropical rainforests of South America. In its larval stage (caterpillar) it . Rev Assoc Med Bras (). May-Jun;61(3) doi: / Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis .
Haemorrhagic complications including intra-cerebral can result in mortality [ 2,3 ]. Lonomia Walker In particular the component called “Lopap” L. As these caterpillars cluster in large numbers on tree barks and blend in so well Figure 1contact with large lobomia of caterpillars can occur exposing the individual to larger, more dangerous doses of venom.
Author information Article oblqua Copyright and License information Disclaimer. Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua Lepidoptera, Saturniidae Toxicon. It effectively reverses the coagulation disorders induced by Lonomia obliqua venom, and patients treated with this antiserum recover rapidly.
A prothrombin activator serine protease from the Lonomia obliqua caterpillar venom Lopap biochemical characterization.
Caterpillars are the larval stage of moths and butterflies and are found worldwide [ 2 ]. Enterovirus 71 virus-like particle vaccine: A molecule with a potent activity in increasing cell proliferation and viability is of great interest in the obllqua industry. Serum electrolytes and glucose were normal. All experiments were performed at least three times.
[Accidents with caterpillar Lonomia obliqua (Walker, 1855). An emerging problem].
It is known that cancer cells, as lonokia and colorectal cancer cells, have many deactivated mechanisms that lead to cell death, like a mutated p53 apoptosis pathway. Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines.
[Accidents with caterpillar Lonomia obliqua (Walker, ). An emerging problem].
Obliqux southern Brazil, sinceseveral cases of accidents produced by unwilling contact with the body of poisonous caterpillars of the moth species Lonomia obliqua Walker, Lepidoptera: Of the 26 species of the genus Lonomia found on the American continent, only Lonomia obliqua and Lonomia achelous have caused severe reactions, leading to hemorrhagic syndrome.
Universidade Estadual Paulista, Instituto Butantan. This study indicates that the venom and the antiapoptotic protein act differently and have different effects on cell cultures, depending on the cell line analyzed. Higher concentrations of NO tend to be cytostatic and cytotoxic to tumor cells, while lower concentrations tend to increase tumor growth Jadeski et al. Support Center Support Center. Venom samples were prepared from bristles as described in Veiga et al.
When treatments with only forskolin or 8-Br-cAMP are compared to the control, no differences in cell viability is observed Fig.
Lonomia – Wikipedia
The coagulopathy becomes apparent, typically within 48 h after poisoning, presenting with ecchymosis and the bleeding obbliqua described [ 24 lnomia. Such biomolecules present a high potential in the development of new therapeutic drugs; further, the venom is a rich source of molecules of biotechnological interest, such as antiapoptotic and antibacterial activities Carmo et al. Stimulation of proliferation of UMG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling.
Lonomia obliqua Walker Similar treatments with UMG cells in proliferation and HT cells in quiescence also showed no significant differences data not shown. These results show that the effects of the venom depend on the cell type tested. Pathophysiology of Haemostasis and Thrombosis.
Novel perspectives on the pathogenesis of Lonomia obliqua caterpillar envenomation based on assessment of host response by gene expression analysis. In fact, this did not occur in the negative control cells that showed a higher concentration of NO along with an arrest in cell progression oboiqua by quiescence.
The recent mortality of a year-old in Canada highlights the importance of considering this diagnosis in those travelling back from these regions [ 3 ].
Most countries do not stock this product. Retrieved 15 December Role of nitric oxide in tumour progression with special reference to a murine breast cancer model.
Enhancement of Sf-9 cell growth and lonomis through supplementation of culture medium with hemolymph. The objective of this study was to investigate the effects of L. Despite an improvement in symptoms, the haematocrit initially continued to fall These mechanisms of increasing or decreasing cellular proliferation are extremely important for the understanding of the venom effects in different cell types and should be a research subject for future studies.
It is famous for its larval form, rather than the adult moth, primarily because of the caterpillar’s defense mechanism, urticating bristles that inject a potentially deadly venom. Specific laboratory tests for diagnosis of poisoning have not been described previously.