• June 18, 2019

Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. Generally, it is idiopathic, although the. Erythema nodosum (EN) is a delayed-type hypersensitivity reaction that most often presents as erythematous, tender nodules on the shins. Erythema nodosum migrans (subacute nodular migratory panniculitis, migratory panniculitis): asymmetrical, unilateral and distributed solely on.

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Pregnancy and oral contraceptive pills The high incidence of EN in females suggests that it is related to sex hormones, confirmed by the more frequent occurrence during pregnancy and when using oral contraceptive pills. Enteropathies 1 to 4 percent: Because of their subcutaneous location, it may require deep palpation.

Continue reading from March 1, Previous: Panniculitis with tender red nodules, usually on both shins. The authors declare no conflict of interest. The role of sex hormones in the aetiopathology of EN and its influence on the immunological system are not sufficiently known.

Histoplasma capsulatum, Blastomyces dermatitidis, Paracoccidioides brasiliensisand Coccidioides immitis have been implicated in the development of erythema nodosum. Lobular without vasculitis Cold Cytophagic histiocytic Factitial Gouty Pancreatic Traumatic needle-shaped clefts Subcutaneous fat necrosis of the newborn Sclerema neonatorum Post-steroid panniculitis Lipodermatosclerosis Weber—Christian disease Lupus erythematosus panniculitis Sclerosing lipogranuloma with vasculitis: The skin of the extensor surface of the lower legs is characterized by a lack of underlying muscle pump and unique coexistence of relatively poor arterial blood supply, rich lymphatic system and difficult venous return caused by gravitational effects.


Each nodule usually heals completely without scarring over the course of about two weeks. For example, in a patient with a history of Hodgkin’s disease, the development of erythema nodosum may reflect recurrence.

Erythema nodosum – Cancer Therapy Advisor

From Wikipedia, the free encyclopedia. It appears as erythematous painful rounded nodules, located most often on the anterior surface of the lower extremities, and may be accompanied by systemic symptoms such as fever, malaise and arthralgia. Development of erythema nodosum in the course of oestrogen replacement therapy. The condition eritma usually relatively harmless, but it can ertema a sign of an underlying infection, other inflammatory conditions, or an abnormal response to an allergen or medication.

How do you treat erythema nodosum?

Review of the literature Erythema nodosum may have a different aetiological factors. However, in many cases it is impossible to determine the cause idiopathic reitema nodosum [ 16 ]. Erythema nodosum is the most common form of panniculitis. Erythema nodosum tends to be self-limited.


Pregnancy 2 to 5 percent. Rare less than 1 percent.

Eritena the other hand, if there is asymmetrical hilar adenopathy or clinical suspicion of either malignancy or etitema, a histopathological examination should be undertaken [ 17 ]. What causes tongue bumps? Skin disorders, after arthritis, uveitis and aphthous stomatitis, are one of the most common extra-intestinal manifestations of inflammatory bowel diseases IBD. Disorders of subcutaneous fat M See My Options close. The overlying skin is red, shiny, and smooth.

Anticipated length of stay.

Sarcoidosis Sarcoidosis is the second most common cause of EN. J Am Acad Dermatol. Sign up for our Email Newsletters. Administration of tamoxifen and anti-estrogens such as aromatase inhibitors was associated with occurrence of the EN [ 4 ].

Underlying infections or medical conditions will also require treatment.

Sarcoidosis causes up to one fourth of erythema nodosum cases. Erythema nodosum may be the first sign of an existent neoplastic disease. In addition, certain medications and even pregnancy can cause erythema nodosum.

It is most common in the eritemaa of 20—30, and affects women 3—6 times more than men.