• June 15, 2019

Pittella JE, de Castro LP. Wernicke’s encephalopathy manifested as Korsakoff’s syndrome in a patient with promyelocytic leukemia. South Med. El beriberi cerebral podría derivar en encefalopatía de Wernicke y psicosis de Korsakoff, especialmente en personas que abusan del alcohol. El diagnóstico de . Wernicke encephalopathy, also referred as Wernicke-Korsakoff syndrome, is due to thiamine (vitamin B1) deficiency, and is typically seen in alcoholics.

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European Journal of Neurology.

If glucose is given, such as in hypoglycaemic alcoholics, thiamine must be given concurrently. A – Pubmed citation. Thiamine can be measured using an erythrocyte transketolase activity assay, [5] or by activation by measurement of in vitro thiamine diphosphate levels.

A neuropathological study with clinical correlations. Childhood obesity Obesity hypoventilation syndrome Abdominal obesity. Also a much more diverse range of symptoms has been found in patients with this condition, including:. Color Atlas of Neurology. Thiamine administration is usually continued until clinical improvement ceases.

Chronic alcoholism was the main cause in the past; currently, there are many other situations which favour this condition: Lesions are usually symmetrical in the periventricular region, diencephalonthe midbrainhypothalamus, and cerebellar vermis. There may be tachycardia, dyspnea, chest pain, orthostatic hypotension, changes in heart rate and blood pressure.

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Alcohol abusers may have poor dietary intakes of several vitamins, and impaired thiamine absorption, metabolism, and storage; they may thus require higher doses. In some countries certain foods have been supplemented with encefalooatia, and have reduced WE cases. Infections have been pointed out as one of the most frequent triggers of death in WE.

[Wernicke’s encephalopathy and Caine criteria. Report of six cases].

However, using the Caine criteria, the diagnosis could be faster in susceptible patients without previous alcoholism. A similar presentation of this disease was described by the Russian psychiatrist Sergei Korsakoff in a series of articles published — In the last stage others symptoms may occur: About Blog Go ad-free.

In patients suspected of WE, thiamine treatment should be started immediately. This criteria is challenged because all the cases he studied were alcoholics. Considering the diversity of possible causes and several surprising symptomatologic presentations, and because there is low assumed risk of toxicity of thiamine, because the therapeutic response is often dramatic from the first day, some qualified authors indicate parenteral thiamine if WE is suspected, both as a resource for diagnosis and treatment.


Despite its name, WE is not related to Wernicke’s area, a region of the brain associated with speech and language interpretation.

Wernicke-Korsakoff Syndrome | Family Caregiver Alliance

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When it occurs simultaneously with alcoholic Korsakoff syndrome it is known as Wernicke—Korsakoff syndrome. The presence of only one sign should korsakogf sufficient for treatment. An overview in health and disease” PDF.

Wernicke encephalopathy

WE was first identified in by the German neurologist Carl Wernickealthough the link with encefalopatja was not identified until the s. Handbook of Clinical Neurology.

Case Reports in Oncology. In patients with Wernicke-Korsakoff syndrome, even higher doses of parenteral thiamine are recommended. Alcoholic encephalopathy Wernicke’s encephalopathy Vitamin B1 deficiency Korsakoff psychosis Korsakoff’s psychosis Thiamine deficiency Wernicke-Korsakoff syndrome. Japanese Journal of Clinical Oncology. Vitamin B 12 deficiency. Thiamine is first metabolised to its more active form, thiamine diphosphate TDPbefore it is used.

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