74178 DATASHEET PDF

  • June 29, 2019

Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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74178 Datasheet

The supporting documents available for this product can be downloaded below. Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody. You will receive an e-mail containing a link to start the recovery procedure within minutes.

Product has been added to your cart. Have trouble resetting your password? If so we’d love to hear about it. Find your product Go. Like most websites, we make use of cookies to track your preferences. Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.

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The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC.

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The modified base itself is stable in vivo and interacts with datzsheet readers including MeCP2 11, Therefore webshop accounts that were only used to view prices have been deleted. This product is intended for research purposes only. TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. Please create a new account with your shipping and billing details if you would like to be able to order or view your discount.

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By proceeding on this website, you agree to the placement of these cookies. Datasheet Datasheet CST As shown in the graph, the antibody only binds to the oligo containing 5-fC.

No need to login to view prices! Since then this datasheer has been discovered in many tissues, with the highest levels found in the brain 9. Login No need to login to view prices! The same sequence of a base pair DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.

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Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation We wish you a successful ! Please change your password to something memorable and secure upon logging in. Please let us know!

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Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, Application References Have 7478 published research involving the use of datasheeh products?

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SN Datasheet(PDF) – TI store

Please refer to this page. Contact us and we will help you. Login Create new account. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian datasneet 1,2.

The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue. You will receive an e-mail from us containing your new password in the coming minutes.

Datasheet PDF – ETC1

While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers. The current items in your cart are: Enter your username and we will send you a link to reset your password if an associated user is found.

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