• June 22, 2019

Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Article by Robert A Schwartz”. From Wikipedia, the free encyclopedia. Jpn J Med ; Eponymous medical signs for oncology. The sign of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses.

Sign of Leser-Trélat

Sign in to save your search Sign in to your personal account. Although most associated neoplasms are gastrointestinal [4] adenocarcinomas stomachlivercolorectal and pancreasmalignancies of the breastlung[5] and urinary tract[6] as well as lymphoid tissue, have been associated with this impressive rash.

Also, seborrheic keratoses may be confused with a plethora of other cutaneous growths including verruca vulgaris, acrochordons, nevi, solar lentigos, lichenoid keratoses, and even cutaneous malignancies such as squamous cell carcinoma or melanoma. Obtaining a thorough history, review or systems, and physical examination may help direct the workup of the patient towards a certain malignancy. Online since 15 th March ‘ Our website uses cookies to enhance your experience.

Leser Trelat Sign – StatPearls – NCBI Bookshelf

The sign of Leser-Trelat. Oxford University Press US.

They are well-circumscribed pigmented lesions with the color ranging from skin tone to tan or brown, and some lesions may appear black. There does not appear to be an increased frequency of a specific histopathological variation of seborrheic keratoses that correlates with the sign of Leser-Trelat.


Laboratory evaluation including a complete blood count CBC and complete metabolic panel CMP should be obtained along with gender-specific cancer screenings such as mammography, Pap smears, and prostate serum antigen PSA testing. Cutaneous manifestations of internal malignancies: Retrieved 15 July However, given the abrupt onset of the seborrheic keratoses and their distinctive sgin misdiagnosis as another cutaneous entity would be unlikely.

If you have any concerns with your skin or its treatment, see a dermatologist for advice. Similar articles in PubMed. Safa G, Darrieux L. Retrieved from ” https: It may possibly be due to the same unknown factors that induce malignant acanthosis nigricans. Kurzrock R, Cohen PR. siyn

Malignant Neoplasms and the Leser-Trélat Sign

Create a free personal account to access your subscriptions, sign up for alerts, and more. They appear as brown warty nodules with a stuck-on appearance. Various subtypes of seborrheic keratoses exist including acanthotic most common varianthyperkeratotic, reticulated, clonal and melanoacanthoma. StatPearls Publishing; Jan.

There is no reported increased predilection amongst either sex or any race. The Oxford illustrated companion to medicine.

The sign of Leser-Trelat in a case of adenocarcinoma of the lung. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content. Examination of the abdomen disclosed moderate hepatosplenomegaly.

Create a free personal account to download free article PDFs, sign up for alerts, and more. Curth’s postulates are a well-known set of clinical criteria that were created to help evaluate the temporal relationship between an underlying malignancy and a specific dermatological condition.


Any of these distinct variations may also become irritated or inflamed, sihn either squamous eddy formation spindled cells trdlat lymphocyte infiltration, respectively. Cutaneous manifestations of internal malignancy.

Support Center Support Center. Poole S, Fenske NA. Febrile neutrophilic dermatosis Pyoderma gangrenosum Paraneoplastic pemphigus. It is thought that paraneoplastic syndromes are caused by the release of hormones trelaat the tumour but this remains to be proven.

Malignant Neoplasms and the Leser-Trélat Sign | JAMA Dermatology | JAMA Network

Create a free personal account to make a comment, download free article PDFs, sign ttrelat for alerts and more. Epub Jan Seborrheic keratoses and cancer. Questions To access free multiple choice questions on this topic, click here. Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more.

Granulocytosis Multicentric reticulohistiocytosis Nonbacterial thrombotic endocarditis. Differential Diagnosis Eruptive seborrheic keratoses have been reported in numerous other clinical scenarios including in patients with erythroderma, pregnant patients, HIV-infected patients, and transplant patients.

Other cancers where the condition has occurred include squamous cell carcinomalymphoma and leukaemia. Two months before, she had noticed the sudden appearance of many “warts” on her face and neck.